Objective: To investigate the efficacy and safety of transbronchial cryobiopsy (TBCB) after lung transplantation. Methods: The clinical characteristics, TBCB procedure, diagnosis and treatment, and outcomes of lung transplant recipients of 6 patients (all male, aged 33-67 years) with TBCB in China-Japan Friendship Hospital from May to November 2021 were retrospectively analyzed. Results: Among the 6 patients diagnosed by TBCB, there were 2 cases of organizing pneumonia, 1 acute cellular rejection, 1 antibody-mediated rejection, and 1 bronchiolitis obliterans, and 1 diffuse alveolar damage. After the clinical diagnosis was confirmed, the condition improved after adjustment of the treatments followed. There were no serious complications related to the TBCB procedure. Conclusion: TBCB is valuable and relatively safe in the diagnosis of complications after lung transplantation, but the indications need to be strictly controlled.
目的： 探讨肺移植术后行经支气管冷冻肺活检（transbronchial cryobiopsy，TBCB）的有效性和安全性。 方法： 回顾性分析2021年5—11月，中日友好医院肺移植术后行TBCB患者6例（均为男性，年龄33~67岁）的临床特征、TBCB操作过程、诊疗经过及转归。 结果： 依据TBCB诊断的6例患者中，有2例机化性肺炎，1例急性细胞性排斥反应，1例抗体介导的排异反应，1例闭塞性细支气管炎，1例弥漫性肺泡损伤。在临床诊断明确后调整后续治疗，病情均好转，均未发生与介入操作相关的严重并发症。 结论： TBCB在肺移植术后并发症诊断中是有价值和相对安全的，但需要严格把握适应证。.