Structural insights into promiscuous GPCR-G protein coupling

Prog Mol Biol Transl Sci. 2023:195:137-152. doi: 10.1016/bs.pmbts.2022.06.015. Epub 2022 Jul 15.

Authors

Ángela Carrión-Antolí¹, Jorge Mallor-Franco¹, Sandra Arroyo-Urea¹, Javier García-Nafría²

Affiliations

¹ Institute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, Zaragoza, Spain.
² Institute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, Zaragoza, Spain. Electronic address: jgarcianafria@unizar.es.

PMID: 36707152
DOI: 10.1016/bs.pmbts.2022.06.015

No abstract available

Keywords: Biased agonism; Cryo-electron microscopy; G protein-coupling promiscuity; G protein-coupling specificity; GPCR; Signaling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

GTP-Binding Proteins* / metabolism
Humans
Ligands
Protein Binding
Receptors, G-Protein-Coupled* / chemistry

Substances

GTP-Binding Proteins
Receptors, G-Protein-Coupled
Ligands