Objective: To summarize the research progress on rodent models of cervical spinal cord injury (SCI).
Methods: The relevant domestic and foreign literature in recent years was reviewed, the methods of establishing the rodent models of cervical SCI and the evaluation methods of behavior, imaging, neuroelectrophysiology, and histology were summarized.
Results: Cervical SCI involves primary and secondary injuries. Primary cervical SCI can be simulated with contusion, contusion compression, fracture dislocation, spinal cord traction, and spinal cord transection; scondary cervical SCI can be simulated with photochemical model and excitotoxicity model. Certain evaluation methods such as behavior, imaging, neuroelectrophysiology, and histology are used to evaluation during model building and research.
Conclusion: Different rodent models of cervical SCI have different advantages and application directions, and it is critical importance for the study of cervical SCI to establish effective animal models.
目的: 总结啮齿动物颈部脊髓损伤（spinal cord injury，SCI）模型的研究进展。.
方法: 查阅近年国内外有关啮齿动物颈部SCI模型的文献，从其建模方法以及行为学、影像学、神经电生理学及组织学评估方法等方面进行总结。.
结果: 颈部SCI包括原发性损伤及继发性损伤，原发性损伤可用挫伤、挫伤压迫、骨折脱位、脊髓牵拉、脊髓横断等模型进行模拟，继发性损伤可用光化学模型及兴奋性毒性模型进行模拟。模型建立及研究过程中常使用行为学、影像学、神经电生理学及组织学等评估方法。.
结论: 不同的啮齿动物颈部SCI模型各有优势及应用方向，建立有效的动物模型对颈部SCI的研究具有重要意义。.
Keywords: Cervical spine cord injury; animal model; model evaluation; rodent.