Gut microbiome lipid metabolism and its impact on host physiology

Abstract

Metabolites produced by commensal gut microbes impact host health through their recognition by the immune system and their influence on numerous metabolic pathways. Notably, the gut microbiota can both transform and synthesize lipids as well as break down dietary lipids to generate secondary metabolites with host modulatory properties. Although lipids have largely been consigned to structural roles, particularly in cell membranes, recent research has led to an increased appreciation of their signaling activities, with potential impacts on host health and physiology. This review focuses on studies that highlight the functions of bioactive lipids in mammalian physiology, with a special emphasis on immunity and metabolism.

Keywords: PUFAs; autoimmune disease; bacteria; cholesterol; diet; inflammation; innate immunity; lipids; metabolism; microbiome; phospholipids; sphingolipids.