In-utero personal exposure to PM2.5 impacted by indoor and outdoor sources and birthweight in the MADRES cohort

Karl O'Sharkey; Yan Xu; Thomas Chavez; Mark Johnson; Jane Cabison; Marisela Rosales; Brendan Grubbs; Claudia M Toledo-Corral; Shohreh F Farzan; Theresa Bastain; Carrie V Breton; Rima Habre

doi:10.1016/j.envadv.2022.100257

In-utero personal exposure to PM_2.5 impacted by indoor and outdoor sources and birthweight in the MADRES cohort

Environ Adv. 2022 Oct:9:100257. doi: 10.1016/j.envadv.2022.100257. Epub 2022 Jun 29.

Authors

Affiliations

¹ Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 2001 N Soto St Rm 102M, Los Angeles, CA 90089, United States.
² Spatial Sciences Institute, University of Southern California, Los Angeles, CA, United States.
³ Department of Health Sciences, California State University Northridge, Northridge, CA, United States.

Abstract

Background: In-utero exposure to outdoor particulate matter with aerodynamic diameter less than 2.5 μm (PM_2.5) is linked with low birthweight. However, previous results are mixed, likely due to measurement error introduced by estimating personal exposure from ambient data. This study investigated the effect of total personal PM_2.5 exposure on birthweight and whether it differed when it was more heavily impacted by sources of indoor vs outdoor origin in the MADRES cohort study.

Methods: Personal PM_2.5 exposure was measured in 205 pregnant women in the 3rd trimester using 48 h integrated, filter-based sampling. Linear regression was used to test the association between personal PM_2.5 exposure and birthweight, adjusting for key covariates. Interactions of PM_2.5 with variables representing indoor sources of PM_2.5, home ventilation, or time spent indoors tested whether the effect of total PM_2.5 on birthweight varied when it was more impacted by sources of indoor vs outdoor origin.

Results: In a sample of largely Hispanic (81%) pregnant women, total personal PM_2.5 was not significantly associated with birthweight (β = 38.6 per 1SD increase in PM_2.5; 95% CI:-21.1, 98.2). This association however, differed by home type (single family home: 156.9 (26.9, 287.0), 2-4 attached units:-16.6 (-111.9, 78.7), 5+ units:-62.6 (-184.9, 59.6), missing: 145.4 (-4.1, 294.9), interaction p = 0.028) and by household air conditioner use (none of the time: -27.6 (-101.5, 46.3) vs. some of the time: 139.9 (42.9, 237.0), interaction p = 0.008) Additionally, the effect of personal PM_2.5 on birthweight varied by time spent indoors (none or little of the time: - 45.1 (-208.3, 118.1) vs. most or all of the time: 57.1 (-7.3, 121.6), interaction p = 0.255).

Conclusions: While no significant association between total personal PM_2.5 exposure and birthweight was found, there was evidence that multi-unit housing (vs. single-family homes), candle and/or incense smoke, and greater outdoor source contributions to personal PM_2.5 were more strongly associated with lower birthweight.

Keywords: Air pollution; Birthweight; PM2.5; Personal monitoring; Pregnancy; Prenatal exposure.

Abstract

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