Electrochemical Isothiocyanation of Primary Amines

Org Lett. 2023 Feb 24;25(7):1147-1150. doi: 10.1021/acs.orglett.3c00128. Epub 2023 Feb 14.

Abstract

Isothiocyanates are ubiquitous building blocks used across the fields. Nevertheless, their classical syntheses very often rely on the use of toxic and expensive reagents. Herein, we report a new practical, mild, high-yielding, and supporting-electrolyte-free electrochemical method for the preparation of aliphatic and aromatic isothiocyanates from amine and carbon disulfide.