Recent management trends of subependymal giant cell astrocytoma associated with tuberous sclerosis complex

J Pak Med Assoc. 2023 Feb;73(2):430-432. doi: 10.47391/JPMA.13-23.

Abstract

Subependymal giant cell astrocytomas (SEGA) are benign cranial tumours typically found in patients with tuberous sclerosis complex (TSC). Surgical resection has been the standard treatment for SEGA, however, medical management through mTOR inhibitors has now predominantly replaced surgery as the primary treatment modality. Additionally, newer treatment modalities have emerged with the hopes of providing safer methods for treating the tumour such as laser interstitial thermal therapy (LITT). However, very few reports have addressed these newer methods and analysed the results.

Keywords: subependymal giant cell astrocytoma; tuberous sclerosis complex; SEGA.

MeSH terms

  • Astrocytoma* / therapy
  • Hope
  • Humans
  • Hyperthermia, Induced*
  • Tuberous Sclerosis* / complications
  • Tuberous Sclerosis* / therapy