Systemic and Cerebral Effects of Physiotherapy in Mechanically Ventilated Subjects

Denise Battaglini; Elena Ciaravolo; Salvatore Caiffa; Lara Delpiano; Lorenzo Ball; Antonio Vena; Daniele R Giacobbe; Matteo Bassetti; Basil Matta; Paolo Pelosi; Chiara Robba; GECOVID Collaborators; GECOVID collaborators:

doi:10.4187/respcare.10227

Systemic and Cerebral Effects of Physiotherapy in Mechanically Ventilated Subjects

Respir Care. 2023 Apr;68(4):452-461. doi: 10.4187/respcare.10227. Epub 2023 Feb 21.

Authors

Collaborators

Iole Brunetti, Nicolò Patroniti, Pasquale Anania, Pietro Fiaschi, Gianluigi Zona, Ayoub Saaid, Robertina Cara, Chiara Pieri, Patricia Rm Rocco

Affiliations

¹ Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy; and Department of Medicine, University of Barcelona, Barcelona, Spain. battaglini.denise@gmail.com.
² Anesthesia and Emergency Department, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy; and Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
³ Intensive Care Respiratory Physiotherapy, Rehabilitation and Functional Education, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy.
⁴ Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy; and Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
⁵ Department of Health Sciences, University of Genoa, Genoa, Italy; and Infectious Diseases Unit, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy.
⁶ Neurocritical Care Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.

Abstract

Background: Physiotherapy may result in better functional outcomes, shorter duration of delirium, and more ventilator-free days. The effects of physiotherapy on different subpopulations of mechanically ventilated patients on respiratory and cerebral function are still unclear. We evaluated the effect of physiotherapy on systemic gas exchange and hemodynamics as well as on cerebral oxygenation and hemodynamics in mechanically ventilated subjects with and without COVID-19 pneumonia.

Methods: This was an observational study in critically ill subjects with and without COVID-19 who underwent protocolized physiotherapy (including respiratory and rehabilitation physiotherapy) and neuromonitoring of cerebral oxygenation and hemodynamics. P_aO₂ /F_IO₂ , P_aCO₂ , hemodynamics (mean arterial pressure [MAP], mm Hg; heart rate, beats/min), and cerebral physiologic parameters (noninvasive intracranial pressure, cerebral perfusion pressure using transcranial Doppler, and cerebral oxygenation using near-infrared spectroscopy) were assessed before (T0) and immediately after physiotherapy (T1).

Results: Thirty-one subjects were included (16 with COVID-19 and 15 without COVID-19). Physiotherapy improved P_aO₂ /F_IO₂ in the overall population (T1 = 185 [108-259] mm Hg vs T0 = 160 [97-231] mm Hg, P = .02) and in the subjects with COVID-19 (T1 = 119 [89-161] mm Hg vs T0 = 110 [81-154] mm Hg, P = .02) and decreased the P_aCO₂ in the COVID-19 group only (T1 = 40 [38-44] mm Hg vs T0 = 43 [38-47] mm Hg, P = .03). Physiotherapy did not affect cerebral hemodynamics, whereas increased the arterial oxygen part of hemoglobin both in the overall population (T1 = 3.1% [-1.3 to 4.9] vs T0 = 1.1% [-1.8 to 2.6], P = .007) and in the non-COVID-19 group (T1 = 3.7% [0.5-6.3] vs T0 = 0% [-2.2 to 2.8], P = .02). Heart rate was higher after physiotherapy in the overall population (T1 = 87 [75-96] beats/min vs T0 = 78 [72-92] beats/min, P = .044) and in the COVID-19 group (T1 = 87 [81-98] beats/min vs T0 = 77 [72-91] beats/min, P = .01), whereas MAP increased in the COVID-19 group only (T1 = 87 [82-83] vs T0 = 83 [76-89], P = .030).

Conclusions: Protocolized physiotherapy improved gas exchange in subjects with COVID-19, whereas it improved cerebral oxygenation in non-COVID-19 subjects.

Keywords: hemodynamic monitoring; neurological complications; oxygenation; rehabilitation; respiratory physiotherapy.

Publication types

Observational Study

MeSH terms

COVID-19* / therapy
Hemodynamics
Humans
Lung
Physical Therapy Modalities
Respiration, Artificial* / methods