Loss of CD34 Expression within an Interstitial Dermal Lymphoid Cell Infiltrate Is a Helpful Clue to the Diagnosis of Morphea

Maged Daruish; Anoud Zidan; Danielle T Greenblatt; Catherine M Stefanato

doi:10.3390/dermatopathology10010010

Loss of CD34 Expression within an Interstitial Dermal Lymphoid Cell Infiltrate Is a Helpful Clue to the Diagnosis of Morphea

Dermatopathology (Basel). 2023 Feb 2;10(1):70-74. doi: 10.3390/dermatopathology10010010.

Authors

Maged Daruish¹, Anoud Zidan¹, Danielle T Greenblatt², Catherine M Stefanato¹

Affiliations

¹ Department of Dermatopathology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
² Pediatric Dermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.

Abstract

A dermal interstitial lymphocytic infiltrate may represent a diagnostic challenge, particularly if the clinical history is not provided. We present three cases within the histological spectrum of morphea in which the immunohistochemical marker CD34 was helpful in confirming the diagnosis.

Keywords: CD34 immunohistochemistry; dermal dendritic cells; morphea.

Publication types

Case Reports

Grants and funding

This research received no external funding.