Autoantibodies targeting to GPER1 promote monocyte cytokines production and inflammation in systemic lupus erythematosus

Xinwei Zhang; Hongyan Qian; Yangchun Chen; Yuanhui Wu; Yuechi Sun; Yan He; Shiju Chen; Guixiu Shi; Yuan Liu

doi:10.1038/s41392-022-01294-3

Autoantibodies targeting to GPER1 promote monocyte cytokines production and inflammation in systemic lupus erythematosus

Signal Transduct Target Ther. 2023 Mar 3;8(1):93. doi: 10.1038/s41392-022-01294-3.

Authors

Xinwei Zhang^#^{1

2

3}, Hongyan Qian^#^{1

2

3}, Yangchun Chen^{1

2

3}, Yuanhui Wu^{1

2

3}, Yuechi Sun^{1

2

3}, Yan He^{1

2

3}, Shiju Chen^{1

2

3}, Guixiu Shi^{4

5

6}, Yuan Liu^{7

8

9}

Affiliations

¹ Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361000, China.
² Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, 361000, China.
³ Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, 361000, China.
⁴ Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361000, China. gshi@xmu.edu.cn.
⁵ Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, 361000, China. gshi@xmu.edu.cn.
⁶ Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, 361000, China. gshi@xmu.edu.cn.
⁷ Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361000, China. liuyuan@xmu.edu.cn.
⁸ Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, 361000, China. liuyuan@xmu.edu.cn.
⁹ Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, 361000, China. liuyuan@xmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies*
Humans
Inflammation
Lupus Erythematosus, Systemic* / genetics
Monocytes
Receptors, Estrogen / metabolism
Receptors, G-Protein-Coupled / metabolism

Substances

Autoantibodies
Receptors, Estrogen
Receptors, G-Protein-Coupled