Invasive Intracoronary Imaging of Cardiac Allograft Vasculopathy: Established Modalities and Emerging Technologies

Negeen Shahandeh; Rushi V Parikh

doi:10.1016/j.iccl.2022.12.005

Invasive Intracoronary Imaging of Cardiac Allograft Vasculopathy: Established Modalities and Emerging Technologies

Interv Cardiol Clin. 2023 Apr;12(2):269-280. doi: 10.1016/j.iccl.2022.12.005.

Authors

Negeen Shahandeh¹, Rushi V Parikh²

Affiliations

¹ Division of Cardiology, University of California, 100 Medical Plaza, Suite 630 East, Los Angeles, CA 90095, USA.
² Division of Cardiology, University of California, Los Angeles, 100 Medical Plaza, Suite 630 West, Los Angeles, CA 90095, USA. Electronic address: rparikh@mednet.ucla.edu.

PMID: 36922067
DOI: 10.1016/j.iccl.2022.12.005

Abstract

Despite advances in the care of heart transplant recipients during the past 5 decades, cardiac allograft vasculopathy (CAV) continues to be a major barrier to long-term survival. The early diagnosis and treatment of CAV is crucial for improving long-term outcomes. Coronary angiography, the current gold standard for CAV screening, has low sensitivity for detecting early CAV. Increasingly, invasive intracoronary imaging modalities that provide a more detailed analysis of vessel anatomy and allow for plaque characterization are being used to detect CAV earlier after transplant and uncover mechanistic insights. Studies validating these emerging imaging platforms are needed before their widespread adoption.

Keywords: Cardiac allograft vasculopathy; Heart transplantation; Intravascular imaging; Intravascular ultrasound; Near-infrared spectroscopy; Optical coherence tomography.

Publication types

Review

MeSH terms

Allografts
Coronary Angiography / methods
Coronary Artery Disease* / diagnosis
Coronary Artery Disease* / etiology
Coronary Artery Disease* / surgery
Heart Transplantation* / adverse effects
Humans
Plaque, Atherosclerotic*