Epilepsy is a neurological disorder characterized by abnormal brain activity. Epileptic patients suffer from unpredictable seizures, which may cause a loss of awareness. Seizures are considered drug resistant if treatment does not affect success. This leads practitioners to calculate the cortical thickness to measure the distance between the brain's white and grey matter surfaces at various locations to perform a surgical intervention. In this study, we introduce using machine learning as an approach to classify extracted measurements from T1-weighted magnetic resonance imaging. Data were collected from the epilepsy unit at King Abdulaziz University Hospital. We applied two trials to classify the extracted measurements from T1-weighted MRI for drug-resistant epilepsy and healthy control subjects. The preprocessing sequence on T1-weighted MRI images was performed using C++ through BrainSuite's pipeline. The first trial was performed on seven different combinations of four commonly selected measurements. The best performance was achieved in Exp6 and Exp7, with 80.00% accuracy, 83.00% recall score, and 83.88% precision. It is noticeable that grey matter volume and white matter volume measurements are more significant than the cortical thickness measurement. The second trial applied four different machine learning classifiers after applying 10-fold cross-validation and principal component analysis on all extracted measurements as in the first trial based on the mentioned previous works. The K-nearest neighbours model outperformed the other machine learning classifiers with 97.11% accuracy, 75.00% recall score, and 75.00% precision.
Keywords: cerebrospinal fluid; cortical thickness; drug-resistant epilepsy; epilepsy; machine learning; magnetic resonance imaging.