Mechanisms of Cardiac Repair in Cell Therapy

Bérénice C Collet; Darryl R Davis

doi:10.1016/j.hlc.2023.01.019

Mechanisms of Cardiac Repair in Cell Therapy

Heart Lung Circ. 2023 Jul;32(7):825-835. doi: 10.1016/j.hlc.2023.01.019. Epub 2023 Apr 6.

Authors

Bérénice C Collet¹, Darryl R Davis²

Affiliations

¹ University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
² University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada. Electronic address: ddavis@ottawaheart.ca.

PMID: 37031061
DOI: 10.1016/j.hlc.2023.01.019

Abstract

Heart failure is an important cause of morbidity and mortality. More than 20 years ago, special interest was drawn to cell therapy as a means of restoring damaged hearts to working condition. But progress has not been straightforward as many of our initial assumptions turned out to be wrong. In this review, we critically examine the last 20 years of progress in cardiac cell therapy and focus on several of the popular beliefs surrounding cell therapy to illustrate the mechanisms involved in restoring heart function after cardiac injury. Are they true or false?

Keywords: Cell therapy; Heart failure; Myocardial infarction; Regeneration.

Copyright © 2023 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

Publication types

Review

MeSH terms

Cell- and Tissue-Based Therapy*
Heart / physiology
Heart Failure* / therapy
Humans
Myocytes, Cardiac
Regeneration