Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0017123. doi: 10.1128/aac.00171-23. Epub 2023 May 3.

Abstract

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.

Keywords: Burkholderia pseudomallei; cefiderocol; resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Burkholderia pseudomallei*
  • Cefiderocol
  • Cephalosporins / pharmacology
  • Cephalosporins / therapeutic use
  • Drug Resistance, Multiple, Bacterial / genetics
  • Gram-Negative Bacteria
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Cephalosporins