Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease

Sephira G Ryman; Nicholas Shaff; Andrew Dodd; Stephanie Nitschke; Christopher Wertz; Kayla Julio; Gerson Suarez Cedeno; Amanda Deligtisch; Erik Erhardt; Henry Lin; Andrei Vakhtin; Kathleen L Poston; Rawan Tarawneh; Sarah Pirio Richardson; Andrew Mayer

doi:10.1002/mds.29429

Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease

Mov Disord. 2023 Jul;38(7):1262-1272. doi: 10.1002/mds.29429. Epub 2023 May 8.

Authors

Sephira G Ryman^{1

2}, Nicholas Shaff¹, Andrew Dodd¹, Stephanie Nitschke¹, Christopher Wertz¹, Kayla Julio¹, Gerson Suarez Cedeno², Amanda Deligtisch², Erik Erhardt³, Henry Lin^{4

5}, Andrei Vakhtin¹, Kathleen L Poston⁶, Rawan Tarawneh⁷, Sarah Pirio Richardson^{2

5}, Andrew Mayer¹

Affiliations

¹ Department of Translational Neuroscience, The Mind Research Network, Albuquerque, New Mexico, USA.
² Nene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.
³ Department of Mathematics and Statistics, University of New Mexico, Albuquerque, New Mexico, USA.
⁴ Department of Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
⁵ Neurology|Medicine, New Mexico VA Health Care System, Albuquerque, New Mexico, USA.
⁶ Movement Disorders Division in the Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
⁷ Memory and Aging Center, Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.

Abstract

Background: Cerebrovascular dysfunction in Parkinson's disease (PD) is heterogeneous and may contribute to disease pathophysiology or progression. There is a need to understand the mechanisms by which cerebrovascular dysfunction is altered in participants with PD.

Objectives: The objective of this study is to test the hypothesis that participants with PD exhibit a significant reduction in the ability of the cerebral vessels to dilate in response to vasoactive challenges relative to healthy controls (HC).

Methods: The current study uses a vasodilatory challenge while participants undergo functional magnetic resonance imaging to quantify the amplitude and delay of cerebrovascular reactivity in participants with PD relative to age and sex-matched HC. An analysis of covariance was used to evaluate differences in cerebrovascular reactivity amplitude and latency between PD participants and HC.

Results: A significant main effect of group was observed for whole-brain cerebrovascular reactivity amplitude (F_{(1, 28)} = 4.38, p = 0.046, Hedge's g = 0.73) and latency (F_{(1, 28)} = 16.35, p < 0.001, Hedge's g = 1.42). Participants with PD exhibited reduced whole-brain amplitude and increased latencies in cerebrovascular reactivity relative to HC. The evaluation of regional effects indicates that the largest effects were observed in the cuneus, precuneus, and parietal regions.

Conclusions: PD participants exhibited reduced and delayed cerebrovascular reactivity. This dysfunction may play an important role in chronic hypoxia, neuroinflammation, and protein aggregation, mechanisms that could lead to disease progression. Cerebrovascular reactivity may serve as an important biomarker and target for future interventions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keywords: MRI; Parkinson's disease; cerebrovascular reactivity.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Brain / pathology
Humans
Magnetic Resonance Imaging / methods
Occipital Lobe
Parietal Lobe
Parkinson Disease*

Abstract

Publication types

MeSH terms

Grants and funding