Delayed Hemolysis With Parenteral Artesunate

Hosp Pharm. 2023 Jun;58(3):259-262. doi: 10.1177/00185787221142471. Epub 2022 Dec 13.

Abstract

Artesunate is an effective and first-line therapy option in patients with severe malaria caused by Plasmodium species. Among adverse effects of the drug is a phenomenon of delayed hemolysis. This usually occurs at least 7 days after initiation of therapy, and is characterized by reductions in hemoglobin and haptoglobin and an increase in lactate dehydrogenase. Here, we report an instance of delayed hemolysis in a patient probably attributed to parenteral artesunate therapy.

Keywords: adverse drug reactions reporting/monitoring; anti-infectives; infectious diseases; intravenous therapy.

Publication types

  • Case Reports