Nasal nitric oxide in healthy Chinese children aged 6-18 years

Yufen Wu; Hao Zhang; Jinrong Wang; Yuling Han; Yongsheng Shi; Qiaoling Zhang; Li Shen; Haohua Jiang; Chunmei Jia; Yanyan Yu; Zhen Long; Minghong Ji; Aihong Liu; Chunhong Pan; Dongjun Ma; Jinhong Wu; Fuli Dai

doi:10.3389/fped.2023.990510

Nasal nitric oxide in healthy Chinese children aged 6-18 years

Front Pediatr. 2023 May 9:11:990510. doi: 10.3389/fped.2023.990510. eCollection 2023.

Authors

Yufen Wu¹, Hao Zhang¹, Jinrong Wang², Yuling Han³, Yongsheng Shi⁴, Qiaoling Zhang⁵, Li Shen⁶, Haohua Jiang⁷, Chunmei Jia⁸, Yanyan Yu⁹, Zhen Long¹⁰, Minghong Ji¹¹, Aihong Liu¹², Chunhong Pan¹, Dongjun Ma¹³, Jinhong Wu¹, Fuli Dai¹⁴

Affiliations

¹ Department of internal medicine, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Pediatric Respiratory Department, The First Affiliate Hospital of Shandong Provincial Medical University, Shandong, China.
³ Department of Respiratory, Children's Hospital Affiliated to Shandong University, Shandong, China.
⁴ Department of Pediatric Respiratory, Maternity and Child-Care Hospital of Gansu Province, Lanzhou, China.
⁵ Department of Pediatric Respiratory, Maternal and Child Health Hospital in Inner Mongolia Autonomous Region, Hohhot, China.
⁶ Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁷ Department of Respiratory Medicine, Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁸ Department of Pediatric Respiratory, The Fourth Hospital of Baotou, Baotou, China.
⁹ Suzhou Municipal Hospital(Suzhou Hospital Affiliated to Nanjing Medical University), Suzhou, China.
¹⁰ Department of Pediatric Respiratory Medicine, Maternal and Child Health Hospital of Hubei Province Affiliated to Huazhong University of Science and Technology Tongji Medical College, Wuhan, China.
¹¹ Department of Pediatric, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Anhui, China.
¹² Department of Respiratory Medicine, Children's Hospital of Shanxi, Taiyuan, China.
¹³ Department of Allergy, Children's Hospital of Urumqi, Urumqi, China.
¹⁴ Department of Pediatric Respiratory Medicine, Luoyang Maternal and Child Health Hospital, Luoyang, China.

Abstract

Objectives: To obtain the normal values of fractional concentration of nasal nitric oxide in Chinese children aged 6-18 years, so as to provide reference for clinical diagnosis.

Methods: 2,580 out of 3,200 children (1,359 males and 1,221 females), whom were included from 12 centers around China were taken tests, their height and weight were also recorded. Data were used to analyze the normal range and influencing factors of fractional concentration of nasal nitric oxide values.

Measurements: Data was measured using the Nano Coulomb Breath Analyzer (Sunvou-CA2122, Wuxi, China), according to the American Thoracic Society/European Respiratory Society (ATS/ERS) recommendations.

Main results: We calculated the normal range and prediction equation of fractional concentration of nasal nitric oxide values in Chinese children aged 6-18 years. The mean FnNO values of Chinese aged 6-18 yrs was 454.5 ± 176.2 ppb, and 95% of them were in the range of 134.5-844.0 ppb. The prediction rule of FnNO values for Chinese children aged 6-11 yrs was: FnNO = 298.881 + 17.974 × age. And for children aged 12-18 yrs was: FnNO = 579.222-30.332 × (male = 0, female = 1)-5.503 × age.

Conclusions: Sex and age were two significant predictors of FnNO values for Chinese children(aged 12-18 yrs). Hopefully this study can provide some reference value for clinical diagnosis in children.

Keywords: Chinese children; factor analysis; fnNO; fractional exhaled nitric oxide testing; reference values.