Curving out a new path: CD28/B7 cis interactions

Xin Ming Matthew Zhou; Alexander M Mørch; Michael L Dustin

doi:10.1016/j.immuni.2023.05.002

Curving out a new path: CD28/B7 cis interactions

Immunity. 2023 Jun 13;56(6):1155-1157. doi: 10.1016/j.immuni.2023.05.002.

Authors

Xin Ming Matthew Zhou¹, Alexander M Mørch¹, Michael L Dustin²

Affiliations

¹ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford, Oxford, UK.
² Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford, Oxford, UK. Electronic address: michael.dustin@kennedy.ox.ac.uk.

PMID: 37315528
DOI: 10.1016/j.immuni.2023.05.002

Abstract

Important signaling events at the immunological synapse have increasingly been linked to cis interactions between receptors on T cells. In this issue of Immunity, Zhao et al.¹ implicate cis CD28/B7 interactions facilitated by curved membrane invaginations in boosting tumor immunity.

Publication types

Comment

MeSH terms

CD28 Antigens*
Endocytosis*
Immunological Synapses
Signal Transduction

Substances

CD28 Antigens