Glycine: a long-sought novel ligand for GPR158

Mette Marie Rosenkilde; Jesper Mosolff Mathiesen

doi:10.1016/j.tips.2023.05.004

Glycine: a long-sought novel ligand for GPR158

Trends Pharmacol Sci. 2023 Aug;44(8):489-491. doi: 10.1016/j.tips.2023.05.004. Epub 2023 Jun 13.

Authors

Mette Marie Rosenkilde¹, Jesper Mosolff Mathiesen²

Affiliations

¹ Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: rosenkilde@sund.ku.dk.
² Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Electronic address: jmm@sund.ku.dk.

PMID: 37321907
DOI: 10.1016/j.tips.2023.05.004

Abstract

G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

Keywords: GPR158; class C GPCRs; glycine; metabotropic receptor.

MeSH terms

Glycine* / pharmacology
Humans
Ligands
Receptors, G-Protein-Coupled*

Substances

Ligands
Glycine
Receptors, G-Protein-Coupled