Vitreoretinal biomarkers of retinopathy of prematurity using handheld optical coherence tomography: a review

Deepika Kubsad; Masis A Ohan; Jolan G Wu; Michelle T Cabrera

doi:10.3389/fped.2023.1191174

Vitreoretinal biomarkers of retinopathy of prematurity using handheld optical coherence tomography: a review

Front Pediatr. 2023 May 31:11:1191174. doi: 10.3389/fped.2023.1191174. eCollection 2023.

Authors

Deepika Kubsad¹, Masis A Ohan¹, Jolan G Wu², Michelle T Cabrera^{2

3}

Affiliations

¹ University of Washington School of Medicine, Seattle, WA, United States.
² Department of Ophthalmology, University of Washington, Seattle, WA, United States.
³ Division of Ophthalmology, Seattle Children's Hospital, Seattle, WA, United States.

Abstract

Retinopathy of prematurity (ROP) is caused by abnormal retinal vascularization in premature infants that has the potential for severe long-term vision impairment. Recent advancements in handheld optical coherence tomography (OCT) have enabled noninvasive, high-resolution, cross-sectional imaging of the infant eye at the bedside. The use of handheld OCT devices in the diagnosis of ROP in premature infants has furthered our understanding of disease state and progression. This review discusses the known and novel biomarkers of ROP severity in premature infants identified through handheld OCT and potential for future directions.

Keywords: childhood blindness; handheld optical coherence tomography; plus disease; preterm infant; retinopathy of prematurity (ROP); vison screening; vitreoretinal biomarkers.

Publication types

Review

Grants and funding

Alcon Research Institute, Violet Sees, Unrestricted Grants from Research to Prevent Blindness and the National Eye Institute (EY00130) to the University of Washington Department of Ophthalmology.