Otorrhea bacterial profile, epidemiology before widespread use of the third-generation pneumococcal conjugate vaccine in French children, a prospective study from 2015 to 2023

Infect Dis Now. 2023 Sep;53(6):104738. doi: 10.1016/j.idnow.2023.104738. Epub 2023 Jun 17.

Abstract

Objectives: The aim of this study was to describe the bacterial profile of middle ear fluid from spontaneous perforation of the tympanic membrane (SPTM) prior to widespread utilization of third- generation pneumococcal conjugate vaccines (PCVs).

Patients and methods: From October 2015 to January 2023, children with SPTM were prospectively enrolled by pediatricians.

Results: Among the 852 children with SPTM, 73.2% were less than 3 years old; more frequently than older children, they were and suffering from complex acute otitis media (AOM) (27.9%) and conjunctivitis (13.1%). In children under 3 years of age, NT Haemophilus influenzae (49.7%) was the main otopathogen isolated, particularly in those with complex AOM (57.1%). In children over 3 years of age, Group A Streptococcus accounted for 57%. In pneumococcal cases (25.1%), serotype 3 was the main serotype isolated (16.2%), followed by 23B (15.2%).

Conclusion: Our data from 2015 to 2023 represent a robust baseline preceding the widespread utilization of next-generation PCVs.

Keywords: Group A Streptococcus; Heamophilus influenzae; Otorrhea; Pneumococcal conjugate vaccines; Streptococcus pneumoniae.

MeSH terms

  • Adolescent
  • Bacteria
  • Child
  • Child, Preschool
  • Humans
  • Otitis Media* / epidemiology
  • Otitis Media* / microbiology
  • Otitis Media* / prevention & control
  • Prospective Studies
  • Streptococcus pneumoniae
  • Vaccines, Conjugate

Substances

  • Vaccines, Conjugate