Comment on Yang et al., 2020: Melatonergic agents in the prevention of delirium: A network meta-analysis of randomized controlled trials

Victor Rodrigues; Sávio Batista; Daniel Lacerda Heringer; Julio Cesar Nunes; Akhil Anand; Penha Cristina Barradas

doi:10.1016/j.smrv.2023.101802

Comment on Yang et al., 2020: Melatonergic agents in the prevention of delirium: A network meta-analysis of randomized controlled trials

Sleep Med Rev. 2023 Aug:70:101802. doi: 10.1016/j.smrv.2023.101802. Epub 2023 Jun 14.

Authors

Victor Rodrigues¹, Sávio Batista², Daniel Lacerda Heringer³, Julio Cesar Nunes⁴, Akhil Anand⁵, Penha Cristina Barradas⁶

Affiliations

¹ Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil. Electronic address: victor.c.rodrigues.med@gmail.com.
² Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
³ Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
⁴ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
⁵ Department of Psychiatry and Psychology, Center for Behavioral Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, USA.
⁶ Department of Pharmacology and Psychobiology, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.

PMID: 37354761
DOI: 10.1016/j.smrv.2023.101802

Abstract

An analysis of delirium prevention considering only older adults is essential. Delirium markedly impacts the older adult population, as it is associated with inpatient occurrence rates from 14% to 56% and hospital mortality rates from 25% to 33% [2]. Ageing comes with a cumulative decline in physiological systems and is a relevant risk factor for chronic diseases [3,4]. Delirium causes in older adults can be multifactorial, including underlying medical conditions, medications, and environmental factors. Therefore, it is vital for healthcare providers to monitor for delirium symptoms in older adults and to implement appropriate interventions, such as addressing underlying medical conditions and addressing possible triggers [5]. Likewise, it is reasonable to think that eventual delirium preventive solutions for older patients would differentiate from the general population.

Publication types

Comment

MeSH terms

Aged
Delirium* / drug therapy
Delirium* / prevention & control
Humans
Network Meta-Analysis
Randomized Controlled Trials as Topic