Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions

Barbara Garita; Jenna Maligro; Saghi Sadoughi; Po Hung Wu; Ellen Liebenberg; Andrew Horvai; Thomas M Link; Galateia J Kazakia

doi:10.1016/j.medntd.2021.100062

Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions

Med Nov Technol Devices. 2021 Jun:10:100062. doi: 10.1016/j.medntd.2021.100062. Epub 2021 Feb 3.

Authors

Barbara Garita¹, Jenna Maligro¹, Saghi Sadoughi¹, Po Hung Wu¹, Ellen Liebenberg², Andrew Horvai³, Thomas M Link¹, Galateia J Kazakia¹

Affiliations

¹ Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
² Department of Orthopaedic Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
³ Department of Pathology, University of California, San Francisco, 1825 4th St, San Francisco, CA, 94143, USA.

Abstract

Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.

Keywords: Cortical bone porosity; HR-pQCT; Type 2 diabetes.

Abstract

Grants and funding