Halogen halos: Report of an early histopathologic finding in iododerma

J Cutan Pathol. 2023 Sep;50(9):806-809. doi: 10.1111/cup.14489. Epub 2023 Jul 2.

Abstract

Iododerma is a rare cutaneous eruption that manifests after exposure to iodine-containing compounds, with few cases reported in the literature. Previous reports of this halogenoderma have described acellular halos simulating cryptococcus on histopathological examination but there is a paucity of reports of biopsies taken early in the disease course. We present a case of a 78-year-old patient who developed a papular eruption after receiving iodinated contrast. A skin biopsy taken within 24 h of the eruption showed a neutrophilic infiltrate with cryptococcal-like acellular haloed structures, indicating that the diagnostic finding may be found early in the disease course.

Keywords: halogen halos; halogenoderma; iododerma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Disease Progression
  • Drug Eruptions* / diagnosis
  • Drug Eruptions* / etiology
  • Drug Eruptions* / pathology
  • Exanthema* / pathology
  • Halogens
  • Humans
  • Skin / pathology

Substances

  • Halogens