'Radiation-induced pleomorphic sarcoma with rhabdomyoblastic differentiation of the lower limb following treatment of vaginal squamous cell carcinoma - A case report and review of the literature'

Anna Nicholson; Alexandra Jolley; Raghu Gowda; Martin K Oehler

doi:10.1016/j.gore.2023.101201

'Radiation-induced pleomorphic sarcoma with rhabdomyoblastic differentiation of the lower limb following treatment of vaginal squamous cell carcinoma - A case report and review of the literature'

Gynecol Oncol Rep. 2023 May 30:48:101201. doi: 10.1016/j.gore.2023.101201. eCollection 2023 Aug.

Authors

Anna Nicholson¹, Alexandra Jolley², Raghu Gowda³, Martin K Oehler¹

Affiliations

¹ Department of Gynaecolocigal Oncology, Royal Adelaide Hospital, Level 5E330, Port Road, Adelaide, SA 5000, Australia.
² SA Pathology, Royal Adelaide Hospital, Adelaide, SA, Australia.
³ Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, SA, Australia.

Abstract

We present the case of a 59-year-old woman who developed a right thigh pleomorphic sarcoma with rhabdomyoblastic differentiation 6 years following radiotherapy for a vaginal squamous cell carcinoma. The overall 5-year survival for a gynaecological malignancy is more than 80 % and as overall cancer survivorship and life expectancy improves, the incidence of radiation-induced malignancy is increasing (Bjerkehagen et al., 2013). As the prognosis of those malignancies is usually poor, clinicians must have a high index of suspicion to try to detect these cases early.

Keywords: Pelvic sarcoma; Post-radiation sarcoma; Radiation-induced sarcoma; Radiotherapy.

Publication types

Case Reports