Palladium-Catalyzed Tandem Diolefination Reaction of Benzaldehyde Enabled by a Remote Directing Group

Org Lett. 2023 Jul 14;25(27):4962-4967. doi: 10.1021/acs.orglett.3c01507. Epub 2023 Jul 5.

Abstract

A tandem diolefination reaction of benzaldehyde has been developed via Pd-catalyzed β-C(sp2)-H olefination of the benzene ring and tandem C(sp2)-H olefination of acrylate. 2-((Aminooxy)methyl)benzonitrile was involved with the benzaldehyde substrate as a remote directing group to realize the C-H bond activation. The control experiments proved that the presence of a remote cyano group is essential for this novel diolefination reaction.

MeSH terms

  • Benzaldehydes*
  • Catalysis
  • Molecular Structure
  • Palladium* / chemistry

Substances

  • Palladium
  • benzaldehyde
  • Benzaldehydes