Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8⁺ T cells

Affiliations

• ¹ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.
• ² CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. liulongchao@im.ac.cn.
• ³ Aetio Biotherapy, Dallas, TX, 75247, USA.
• ⁴ Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
• ⁵ Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
• ⁶ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. Jian.Qiao@UTSouthwestern.edu.
• ⁷ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. yangxinfu@tsinghua.edu.cn.
• ⁸ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. yangxinfu@tsinghua.edu.cn.