Topical Application of M89PF Containing Vichy Mineralising Water and Probiotic Fractions Prevents Cutaneous Damage Induced by Exposure to UV and O3

Abstract

Purpose: Exposure of the skin to ultraviolet radiation (UV) or ozone (O₃) results in stressed skin, leading to the alteration of the skin physical barrier and defence functions. In this work, the preventive benefit of a dermocosmetic, M89PF, containing Vichy mineralising water, probiotic fractions, antioxidant vitamins and hyaluronic acid, in the alteration of skin physical barrier and skin defence functions after exposure to O₃ and UV, alone or combined, was assessed.

Methods: Untreated and treated (M89PF) skin explants were exposed to O₃, to UV rays or to O₃+UV. Immunofluorescence was performed for skin barrier, oxidative stress, and inflammatory markers after one and four days of exposure to the pollutants.

Results: M89PF significantly (p≤0.05) prevented the decrease of the expression level of different skin barrier markers, and significantly (p≤0.05) prevented the induction of OxInflammatory markers and inflammasome components by UV, O_3, or both combined.

Conclusion: M89PF prevents skin barrier damage, as well as oxidative stress and inflammatory markers induced by exposome factors, such as UV, O_3, or both combined.

Keywords: inflammation; oxidative stress; ozone; skin barrier; ultraviolet radiation.