Efficacy and tolerability of desvenlafaxine in the real-world treatment of patients with major depression: a narrative review and an expert opinion paper

Expert Opin Pharmacother. 2023 Sep-Dec;24(14):1511-1525. doi: 10.1080/14656566.2023.2237410. Epub 2023 Jul 23.

Abstract

Introduction: Major depressive disorder (MDD) is a common severe mental disorder, requiring a tailored and integrated treatment. Several approaches are available including different classes of antidepressants various psychotherapeutic approaches, and psychosocial interventions. The treatment plan for each patient with MDD should be differentiated on the basis of several clinical, personal, and contextual factors.

Areas covered: Desvenlafaxine - a serotonine-noradrenergic reuptake inhibitor (SNRI) antidepressant - has been approved in the United States in 2008 for the treatment of MDD in adults, and has been recently rediscovered by clinicians due to its good side-effect profile and its clinical effectiveness. A narrative review on efficacy, tolerability and use of desvenlafaxine in clinical practice was carried out. The keywords: 'major depression', 'depression,' 'desvenlafaxine,' 'efficacy,' 'clinical efficacy,' 'side effects', 'tolerability,' 'elderly patients', 'consultation-liaison', 'menopausal', 'young people', 'adolescent' were entered in PubMed, ISI Web of Knowledge, Scopus and Medline. No time limit was fixed, the search strategy was implemented on May 10, 2023.

Expert opinion: Desvenlafaxine should be listed among the optimal treatment strategies for managing people with MDD, whose main strengths are: 1) ease of dosing; 2) favorable safety and tolerability profile, 3) absence of sexual dysfunctions, weight gain and low rate of discontinuation symptoms; 4) low risk of drug-drug interactions.

Keywords: depression; desvenlafaxine; effectiveness; efficacy; safety; tolerability.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Antidepressive Agents / adverse effects
  • Cyclohexanols / therapeutic use
  • Depression
  • Depressive Disorder, Major* / drug therapy
  • Desvenlafaxine Succinate / adverse effects
  • Drug-Related Side Effects and Adverse Reactions*
  • Expert Testimony
  • Humans

Substances

  • Desvenlafaxine Succinate
  • Cyclohexanols
  • Antidepressive Agents