Animal models of complex regional pain syndrome: A scoping review

Juliete Palandi; Josiel Mileno Mack; Isabela Longo de Araújo; Marcelo Farina; Franciane Bobinski

doi:10.1016/j.neubiorev.2023.105324

Animal models of complex regional pain syndrome: A scoping review

Neurosci Biobehav Rev. 2023 Sep:152:105324. doi: 10.1016/j.neubiorev.2023.105324. Epub 2023 Jul 17.

Authors

Juliete Palandi¹, Josiel Mileno Mack², Isabela Longo de Araújo², Marcelo Farina¹, Franciane Bobinski³

Affiliations

¹ Laboratory of Experimental in Neuropathology (LEN), Graduate Program in Neuroscience, Biochemistry Department, Biological Sciences Center, Universidade Federal de Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazil.
² Laboratory of Experimental Neuroscience (LaNEx), Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina (UNISUL), 88137-272 Palhoça, SC, Brazil.
³ Laboratory of Experimental Neuroscience (LaNEx), Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina (UNISUL), 88137-272 Palhoça, SC, Brazil. Electronic address: franciane.bobinski@animaeducacao.com.br.

PMID: 37467905
DOI: 10.1016/j.neubiorev.2023.105324

Abstract

Background: complex regional pain syndrome (CRPS) leads to a debilitating chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely explored in animal models.

Objective: Provide a comprehensive framework of the animal models used for investigating CRPS.

Eligibility criteria: Preclinical studies to induce the characteristics of CRPS, with a control group, in any language or publication date.

Sources of evidence: The search was performed in the Medline (PubMed) and ScienceDirect databases.

Results: 93 studies are included. The main objective of the included studies was to understand the CRPS model. Rats, males and adults, exposed to ischemia/reperfusion of the paw or fracture of the tibia were the most common characteristics. Nociceptive evaluation using von Frey monofilaments was the most widely adopted in the studies.

Conclusions: For the best translational science between the animal models and individuals with CRPS, future studies should include more heterogeneous animals, and multiple assessment tools, in addition to improving the description and performance of measures that reduce the risk of bias.

Keywords: Animal models; Complex Regional Pain Syndrome; Preclinical research; Scoping review.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chronic Pain*
Complex Regional Pain Syndromes* / drug therapy
Complex Regional Pain Syndromes* / etiology
Disease Models, Animal
Male
Pain Measurement
Rats