Occurrence and outcome of COVID-19 in AIRD patients on concomitant treatment with Tofacitinib- results from KRA COVID COHORT (KRACC) subset

Pramod Chebbi; Vineeta Shobha; Vijay K Rao; Vikram Haridas; Ramya Janardana; Benzeeta Pinto; Sharath Kumar; Abhishek Patil; Roopa Tekkatte; Manasa Salanke; K M Mahendranath

doi:10.1186/s41927-023-00345-8

Occurrence and outcome of COVID-19 in AIRD patients on concomitant treatment with Tofacitinib- results from KRA COVID COHORT (KRACC) subset

BMC Rheumatol. 2023 Jul 26;7(1):22. doi: 10.1186/s41927-023-00345-8.

Authors

Affiliations

¹ Department of Rheumatology, SDMCMSH, SDM University Dharwad, Dharwad, India.
² Department of Clinical Immunology and Rheumatology, St.John's Medical college Hospital, Sarjapur Road, Bengaluru, 560034, India. vineeta.s@stjohns.in.
³ Department of Rheumatology, Manipal Hospital, Bengaluru, India.
⁴ Arthritis Superspeciality Center, Hubli, India.
⁵ Department of Clinical Immunology and Rheumatology, St.John's Medical college Hospital, Sarjapur Road, Bengaluru, 560034, India.
⁶ OPTIMA Rheumatology & Arthritis clinic, Bengaluru, India.
⁷ Aster RV hospital, Bengaluru, India.
⁸ ChanRe Rheumatology and Immunology Centre, Bangalore, India.
⁹ Samarpan Health center, Bangalore, India.

Abstract

Introduction: We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment with tofacitinib.

Methods: This is a non-interventional, cross-sectional, questionnaire based telephonic study which included consecutive AIRD patients on tofacitinib co-treatment. Data related to the AIRD subset, disease modifying anti rheumatic drugs(DMARDs) including glucocorticoids and comorbidities, was collected from 7 rheumatology centers across Karnataka during the second wave of COVID-19 pandemic. The information about COVID-19 occurrence and COVID-19 vaccination was recorded.

Results: During the study period (Jun-July 2021), 335 AIRD patients (80.6% female) on treatment with tofacitinib were included. The mean duration of tofacitinib use was 3.4+/-3.1months. Thirty-six(10.75%) patients developed COVID-19. Diabetes mellitus (p = 0.04 (OR 2.60 (1.13-5.99)) was identified as a risk factor for COVID-19 in our cohort. Almost half of our cohort was COVID-19 vaccinated with at least one dose, with resultant decline in incidence of COVID-19(OR 0.15 (0.06-0.39) among the vaccinated. Recovery amongst COVID-19 infection group was 91.2%.

Conclusions: The subset of AIRD patients who were on treatment with tofacitinib were found to have a higher rate of COVID-19 infection as compared to our KRACC cohort. Pre-existing comorbidity of diabetes mellitus was the significant risk factor in our cohort. This subset of the KRACC cohort shows RA patients had a lesser infection and PsA patients had a higher infection.

Keywords: Autoimmune rheumatic diseases; Concomitant tofacitinib treatment; Covid-19; SARS-CoV-2 infection.