Total syntheses of macleanine and lycoposerramine-S

Org Biomol Chem. 2023 Aug 9;21(31):6289-6292. doi: 10.1039/d3ob01065a.

Abstract

Total syntheses of fawcettimine-class Lycopodium alkaloids having an imino bridge between C5 and C13 were accomplished. Fawcettimine was first prepared in 10 steps from a known compound, and the characteristic structures, including the imino bridge, were constructed via the formation of a bridgehead imine.