Hydrogen production from electrocatalytic water splitting driven by renewable energy sources provides a promising path for energy sustainability. The current water electrolysis technologies mainly use fresh water as feedstock, which will further aggravate the shortage of water resources in the world. Seawater has an innate advantage in large-scale electrolysis hydrogen production because of its abundant reserves. However, direct seawater electrolysis without any pre-treatment faces serious challenges due to the electrode side reactions and corrosion issues caused by the complex compositions of seawater. In this review, we first discuss the basic principles of seawater electrolysis. Second, the recent progress in designing efficient direct seawater electrolysis systems is discussed in detail, including catalyst design, electrolyser assembly, membrane regulation, and electrolyte engineering. In addition, the challenges and future opportunities are highlighted for the development of seawater splitting technologies toward large-scale hydrogen production.