Management of Lupus Nephritis: New Treatments and Updated Guidelines

Kidney360. 2023 Oct 1;4(10):1503-1511. doi: 10.34067/KID.0000000000000230.

Abstract

Management of lupus nephritis has evolved considerably over the past years. Here, we provide a comprehensive review of clinical trials that form the basis for the Kidney Disease: Improving Global Outcomes and EULAR/ERA-EDTA updated guidelines and present day trials that will change the landscape of lupus nephritis therapy in years to come. In addition, we highlight the issues related to cost of therapy, resistant disease, and downstream adverse effects of specific therapies.

Trial registration: ClinicalTrials.gov NCT04221477 NCT03597464 NCT04181762 NCT04376827 NCT05138133 NCT04564339 NCT05268289 NCT05097989 NCT03393013.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Lupus Nephritis* / drug therapy

Associated data

  • ClinicalTrials.gov/NCT04221477
  • ClinicalTrials.gov/NCT03597464
  • ClinicalTrials.gov/NCT04181762
  • ClinicalTrials.gov/NCT04376827
  • ClinicalTrials.gov/NCT05138133
  • ClinicalTrials.gov/NCT04564339
  • ClinicalTrials.gov/NCT05268289
  • ClinicalTrials.gov/NCT05097989
  • ClinicalTrials.gov/NCT03393013