YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury

Antioxid Redox Signal. 2024 Jun;40(16-18):889-905. doi: 10.1089/ars.2023.0291. Epub 2023 Nov 10.

Authors

Ping Pang¹, Wei Si¹, Han Wu¹, Jiaming Ju¹, Kuiwu Liu¹, Chunlei Wang¹, Yingqiong Jia¹, Hongtao Diao¹, Linghua Zeng¹, Weitao Jiang¹, Yang Yang¹, Yuting Xiong¹, Xue Kong¹, Zhengwei Zhang¹, Feng Zhang¹, Jinglun Song¹, Ning Wang¹, Baofeng Yang¹, Yu Bian¹

Affiliation

¹ Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.

PMID: 37548549
DOI: 10.1089/ars.2023.0291

No abstract available

Keywords: YTHDF2; ferroptosis; ischemia–reperfusion injury; oxidative stress; reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Transport System y+* / genetics
Amino Acid Transport System y+* / metabolism
Animals
Ferroptosis* / genetics
Humans
Mice
Myocardial Reperfusion Injury* / genetics
Myocardial Reperfusion Injury* / metabolism
Myocardial Reperfusion Injury* / pathology
Proteolysis
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism

Substances

Amino Acid Transport System y+
RNA-Binding Proteins
SLC7A11 protein, human