RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Marian C Brady; Myzoon Ali; Kathryn VandenBerg; Linda J Williams; Louise R Williams; Masahiro Abo; Frank Becker; Audrey Bowen; Caitlin Brandenburg; Caterina Breitenstein; Stefanie Bruehl; David A Copland; Tamara B Cranfill; Marie di Pietro-Bachmann; Pamela Enderby; Joanne Fillingham; Federica Lucia Galli; Marialuisa Gandolfi; Bertrand Glize; Erin Godecke; Neil Hawkins; Katerina Hilari; Jacqueline Hinckley; Simon Horton; David Howard; Petra Jaecks; Elizabeth Jefferies; Luis M T Jesus; Maria Kambanaros; Eun Kyoung Kang; Eman M Khedr; Anthony Pak-Hin Kong; Tarja Kukkonen; Marina Laganaro; Matthew A Lambon Ralph; Ann Charlotte Laska; Béatrice Leemann; Alexander P Leff; Roxele R Lima; Antje Lorenz; Brian MacWhinney; Rebecca Shisler Marshall; Flavia Mattioli; Ilknur Maviş; Marcus Meinzer; Reza Nilipour; Enrique Noé; Nam-Jong Paik; Rebecca Palmer; Ilias Papathanasiou; Brigida F Patricio; Isabel Pavão Martins; Cathy Price; Tatjana Prizl Jakovac; Elizabeth Rochon; Miranda L Rose; Charlotte Rosso; Ilona Rubi-Fessen; Marina B Ruiter; Claerwen Snell; Benjamin Stahl; Jerzy P Szaflarski; Shirley A Thomas; Mieke van de Sandt-Koenderman; Ineke van der Meulen; Evy Visch-Brink; Linda Worrall; Heather Harris Wright

doi:10.1080/02687038.2019.1643003

RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Aphasiology. 2020 Feb;34(2):137-157. doi: 10.1080/02687038.2019.1643003.

Authors

Marian C Brady¹, Myzoon Ali¹, Kathryn VandenBerg¹, Linda J Williams², Louise R Williams¹, Masahiro Abo³, Frank Becker⁴, Audrey Bowen⁵, Caitlin Brandenburg⁶, Caterina Breitenstein⁷, Stefanie Bruehl⁸, David A Copland⁶, Tamara B Cranfill⁹, Marie di Pietro-Bachmann¹⁰, Pamela Enderby¹¹, Joanne Fillingham¹², Federica Lucia Galli¹³, Marialuisa Gandolfi¹⁴, Bertrand Glize¹⁵, Erin Godecke¹⁶, Neil Hawkins¹⁷, Katerina Hilari¹⁸, Jacqueline Hinckley¹⁹, Simon Horton²⁰, David Howard²¹, Petra Jaecks²², Elizabeth Jefferies²³, Luis M T Jesus²⁴, Maria Kambanaros²⁵, Eun Kyoung Kang²⁶, Eman M Khedr²⁷, Anthony Pak-Hin Kong²⁸, Tarja Kukkonen²⁹, Marina Laganaro³⁰, Matthew A Lambon Ralph³¹, Ann Charlotte Laska³², Béatrice Leemann³³, Alexander P Leff³⁴, Roxele R Lima³⁵, Antje Lorenz³⁶, Brian MacWhinney³⁷, Rebecca Shisler Marshall³⁸, Flavia Mattioli³⁹, Ilknur Maviş⁴⁰, Marcus Meinzer⁴¹, Reza Nilipour⁴², Enrique Noé⁴³, Nam-Jong Paik⁴⁴, Rebecca Palmer¹¹, Ilias Papathanasiou⁴⁵, Brigida F Patricio⁴⁶, Isabel Pavão Martins⁴⁷, Cathy Price⁴⁸, Tatjana Prizl Jakovac⁴⁹, Elizabeth Rochon⁵⁰, Miranda L Rose⁵¹, Charlotte Rosso⁵², Ilona Rubi-Fessen⁵³, Marina B Ruiter⁵⁴, Claerwen Snell⁵⁵, Benjamin Stahl⁵⁶, Jerzy P Szaflarski⁵⁷, Shirley A Thomas⁵⁸, Mieke van de Sandt-Koenderman⁵⁹, Ineke van der Meulen⁵⁹, Evy Visch-Brink⁶⁰, Linda Worrall⁶, Heather Harris Wright⁶¹

Affiliations

¹ Nursing Midwifery and Allied Health Professions Unit, Glasgow Caledonian University, Glasgow, UK.
² Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
³ Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan.
⁴ University of Oslo, Oslo, and Sunnaas Rehabilitation Hospital, Bjørnemyr, Norway.
⁵ Division of Neuroscience & Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
⁶ School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia.
⁷ Department of Neurology with Institute of Translational Neurology, University of Muenster, Muenster, Germany.
⁸ School of Biological Sciences, University of Manchester, Manchester, UK.
⁹ Special Education, Eastern Kentucky University, Richmond, KY, USA.
¹⁰ Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland.
¹¹ School of Health and Related Research, University of Sheffield, Sheffield, UK.
¹² Nursing Directorate, NHS Improvement, London, UK.
¹³ Neurorehabilitation Clinic, Neurological Sciences Department, Marche Polytechnic University, Ancona, Italy.
¹⁴ Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
¹⁵ EA 4136 Handicap Activity Cognition Health, University of Bordeaux and Department of Physical Medicine and Rehabilitation, CHU de Bordeaux, France.
¹⁶ School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
¹⁷ Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
¹⁸ Division of Language and Communication Science, City, University of London, London, UK.
¹⁹ Department of Speech-Language Pathology, Nova Southeastern University, Fort Lauderdale, FL, USA.
²⁰ School of Health Sciences, University of East Anglia, Norwich, UK.
²¹ School of Education Communication and Language Sciences, Newcastle University, Newcastle-Upon-Tyne, UK.
²² Faculty of Linguistics and Literary Studies, Bielefeld University, Bielefeld, Germany.
²³ Department of Psychology, University of York, York, UK.
²⁴ School of Health Sciences (ESSUA) and Institute of Electronics and Informatics Engineering of Aveiro (IEETA), University of Aveiro, Aveiro, Portugal.
²⁵ Department of Rehabilitation Sciences, Cyprus University of Technology, Limassol, Cyprus.
²⁶ Department of Rehabilitation Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.
²⁷ Department of Neurology, Assiut University Hospital, Assiut, Egypt.
²⁸ School of Communication Sciences and Disorders, University of Central Florida, Orlando, FL, USA.
²⁹ ENT/Department of Phoniatry, Tampere University Hospital, Tampere, Finland.
³⁰ Faculty of Psychology and Educational Science, University of Geneva, Geneva, Switzerland.
³¹ MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
³² Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
³³ Neurorééducation, Département des Neurosciences Cliniques, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
³⁴ Department of Brain Repair and Rehabilitation, Institute of Neurology, UCL, London, UK.
³⁵ Department of Speech Language Pathology, Educational Association Bom Jesus - IELUSC, Santa Catarina, Brazil.
³⁶ Institut für Psychologie, Humboldt University Berlin, Berlin, Germany.
³⁷ Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.
³⁸ Department of Communication Sciences and Special Education, University of Georgia, Georgia, USA.
³⁹ Neuropsychology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.
⁴⁰ Department of Speech and Language Therapy, Anadolu University, Eskişehir, Turkey.
⁴¹ UQ Centre for Clinical Research, The University of Queensland, Hertston, Australia.
⁴² Department of Speech Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
⁴³ NEURORHB-Hospitales Vithas, Valencia, Spain.
⁴⁴ Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
⁴⁵ Department of Speech and Language Therapy, Technological Educational Institute of Western Greece, Patras, Greece.
⁴⁶ Speech Therapy Department of Health School of Polytechnic Institute of Porto, Porto, Portugal.
⁴⁷ Laboratório de Estudos de Linguagem, Faculdade de Medicina de Lisboa, Universidade de Lisboa, Lisbon, Portugal.
⁴⁸ Wellcome Centre for Human Neuroimaging, UCL, London, UK.
⁴⁹ Department of Speech and Language Pathology, Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb, Croatia.
⁵⁰ Department of Speech-Language Pathology and Rehabilitation Sciences Institute, University of Toronto, and Toronto Rehabilitation Institute, Toronto, Canada.
⁵¹ School of Allied Health, La Trobe University, Melbourne, Australia.
⁵² Institut du Cerveau et del la Moelle épinière, Sorbonne University, APHP, Urgences Cérébro-Vasculaires, Hôpital de la Pitié Salpêtrière, Paris, France.
⁵³ RehaNova Rehabilitation Hospital and Department of Special Education and Rehabilitation, University of Cologne, Cologne, Germany.
⁵⁴ Sint Maartenskliniek, Rehabilitation Centre and Centre for Language Studies, Radboud University, Nijmegen, The Netherlands.
⁵⁵ Warrington Hospital, Warrington and Halton NHS Foundation Trust, Warrington, UK.
⁵⁶ Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.
⁵⁷ UAB Epilepsy Centre, Department of Neurology, University of Alabama at Birmingham, AL, USA.
⁵⁸ Division of Rehabilitation & Ageing; School of Medicine, University of Nottingham, Nottingham, UK.
⁵⁹ Rijndam rehabilitation Rotterdam and Erasmus University Medical Center, Rotterdam, Netherlands.
⁶⁰ Department of Neurology and Neurosurgery, Erasmus University Medical Center, Rotterdam, Netherlands.
⁶¹ College of Allied Health Sciences, East Carolina University, Greenville, SC, USA.

Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.

Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.

Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.

Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.

Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.

Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947).

Keywords: IPD; Stroke; aphasia; complex intervention; meta-analysis.