Wild-Type Transthyretin Cardiac Amyloidosis in a Transplanted Heart

Lily K Stern; Pamela A Ivey; Corey J Lum; Shayaan Zaidi; Daniel Luthringer; Angela Velleca; Jon A Kobashigawa; Jignesh K Patel; Michelle M Kittleson

doi:10.1016/j.jaccas.2023.101935

Wild-Type Transthyretin Cardiac Amyloidosis in a Transplanted Heart

JACC Case Rep. 2023 Jun 23:19:101935. doi: 10.1016/j.jaccas.2023.101935. eCollection 2023 Aug 2.

Authors

Lily K Stern¹, Pamela A Ivey², Corey J Lum², Shayaan Zaidi², Daniel Luthringer³, Angela Velleca¹, Jon A Kobashigawa¹, Jignesh K Patel¹, Michelle M Kittleson¹

Affiliations

¹ Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
² Department of Cardiology, Intermountain Healthcare, Las Vegas, Nevada, USA.
³ Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Abstract

Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is more prevalent than appreciated in the elderly. We present the case of an 88-year-old woman who underwent heart transplantation for ischemic cardiomyopathy and then presented 21 years later with new onset atrial flutter, found on endomyocardial biopsy to have new ATTRwt-CM. (Level of Difficulty: Advanced.).

Keywords: amyloid cardiomyopathy; cardiac amyloidosis; heart transplantation; wild-type transthyretin.

Publication types

Case Reports