Functional drug-delivery hydrogels for oral and maxillofacial wound healing

Ming Hao; Dongxu Wang; Mengna Duan; Shaoning Kan; Shuangji Li; Han Wu; Jingcheng Xiang; Weiwei Liu

doi:10.3389/fbioe.2023.1241660

Functional drug-delivery hydrogels for oral and maxillofacial wound healing

Front Bioeng Biotechnol. 2023 Aug 3:11:1241660. doi: 10.3389/fbioe.2023.1241660. eCollection 2023.

Authors

Ming Hao^{1

2}, Dongxu Wang³, Mengna Duan⁴, Shaoning Kan^{1

2}, Shuangji Li^{1

2}, Han Wu^{1

2}, Jingcheng Xiang^{1

2}, Weiwei Liu^{1

2}

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, China.
² Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, China.
³ Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
⁴ Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China.

Abstract

The repair process for oral and maxillofacial injuries involves hemostasis, inflammation, proliferation, and remodeling. Injury repair involves a variety of cells, including platelets, immune cells, fibroblasts, and various cytokines. Rapid and adequate healing of oral and maxillofacial trauma is a major concern to patients. Functional drug-delivery hydrogels play an active role in promoting wound healing and have shown unique advantages in wound dressings. Functional hydrogels promote wound healing through their adhesive, anti-inflammatory, antioxidant, antibacterial, hemostatic, angiogenic, and re-epithelialization-promoting properties, effectively sealing wounds and reducing inflammation. In addition, functional hydrogels can respond to changes in temperature, light, magnetic fields, pH, and reactive oxygen species to release drugs, enabling precise treatment. Furthermore, hydrogels can deliver various cargos that promote healing, including nucleic acids, cytokines, small-molecule drugs, stem cells, exosomes, and nanomaterials. Therefore, functional drug-delivery hydrogels have a positive impact on the healing of oral and maxillofacial injuries. This review describes the oral mucosal structure and healing process and summarizes the currently available responsive hydrogels used to promote wound healing.

Keywords: drug delivery; functional hydrogel; oral and maxillofacial; skin repair; wound healing.

Publication types

Review

Grants and funding

This work was supported by the Jilin Province Department of Finance (Grant No. jcsz2021893-13), the Jilin Scientific and Technological Development Program (Grant Nos. YDZJ202301ZYTS166 and 20200801077GH), Jilin University Baikouen Program Project (Grant No. 2023B26), Jilin Provincial Education Department Science and Technology Research Project (Grant No. JJKH20221093KJ), Jilin University Cross disciplinary Cultivation Program for Young Faculty and Students (Grant No. 2022-JCXK-10), Jilin Province Development and Reform Commission (Grant No. 2023C028-6), and the Changchun Scientific and Technological Development Program (Grant No. 21ZY26).