Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

Qi Yan; Rafael F Guerrero; Raiyan R Khan; Andy A Surujnarine; Ronald J Wapner; Matthew W Hahn; Anita Raja; Ansaf Salleb-Aouissi; William A Grobman; Hyagriv Simhan; Nathan R Blue; Robert Silver; Judith H Chung; Uma M Reddy; Predrag Radivojac; Itsik Pe'er; David M Haas

doi:10.1093/genetics/iyad151

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

Genetics. 2023 Oct 4;225(2):iyad151. doi: 10.1093/genetics/iyad151.

Authors

Qi Yan¹, Rafael F Guerrero^{2

3}, Raiyan R Khan⁴, Andy A Surujnarine¹, Ronald J Wapner¹, Matthew W Hahn^{2

5}, Anita Raja⁶, Ansaf Salleb-Aouissi⁴, William A Grobman⁷, Hyagriv Simhan⁸, Nathan R Blue⁹, Robert Silver⁹, Judith H Chung¹⁰, Uma M Reddy¹, Predrag Radivojac¹¹, Itsik Pe'er⁴, David M Haas¹²

Affiliations

¹ Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA.
² Department of Computer Science, Indiana University, Bloomington, IN 47405, USA.
³ Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
⁴ Department of Computer Science, Columbia University, New York, NY 10032, USA.
⁵ Department of Biology, Indiana University, Bloomington, IN 47405, USA.
⁶ Department of Computer Science, CUNY Hunter College, New York, NY 10065, USA.
⁷ Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
⁸ Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.
⁹ Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA.
¹⁰ Department of Obstetrics and Gynecology, University of California, Irvine, Orange, CA 92697, USA.
¹¹ Khoury College of Computer Sciences, Northeastern University, Boston, MA 02115, USA.
¹² Department of Obstetrics and Gynecology, Indiana University, Indianapolis, IN 46202, USA.

Abstract

Adverse pregnancy outcomes (APOs) are major risk factors for women's health during pregnancy and even in the years after pregnancy. Due to the heterogeneity of APOs, only few genetic associations have been identified. In this report, we conducted genome-wide association studies (GWASs) of 479 traits that are possibly related to APOs using a large and racially diverse study, Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b). To display extensive results, we developed a web-based tool GnuMoM2b (https://gnumom2b.cumcobgyn.org/) for searching, visualizing, and sharing results from a GWAS of 479 pregnancy traits as well as phenome-wide association studies of more than 17 million single nucleotide polymorphisms. The genetic results from 3 ancestries (Europeans, Africans, and Admixed Americans) and meta-analyses are populated in GnuMoM2b. In conclusion, GnuMoM2b is a valuable resource for extraction of pregnancy-related genetic results and shows the potential to facilitate meaningful discoveries.

Keywords: GWAS; PheWAS; adverse pregnancy outcomes; nuMoM2b.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Female
Genome-Wide Association Study* / methods
Humans
Phenomics*
Phenotype
Polymorphism, Single Nucleotide
Pregnancy
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding