A unique association? A narcolepsy type 1 case comorbid with Primary Biliary Cholangitis

Sleep Med. 2023 Oct:110:180-182. doi: 10.1016/j.sleep.2023.08.015. Epub 2023 Aug 18.

Abstract

The aim of the study was to present a woman affected of a narcolepsy with cataplexy (narcolepsy type 1) comorbid with an asymptomatic Primary Biliary Cholangitis (PBC). The HLA haplotype was DRB1*15:01, DQA1*01:02, DQB1*06:02. The allele DQB1*06:02 has been considered until now protective for PBC and dual pathology has not been published. We think the important clinical message of the Case would be of continuing to monitor adults with narcolepsy type 1 for late complications that may be associated with other autoimmune conditions. Clinicians should be aware of the relationship between Narcolepsy and PBC. This highlights the need for screening and management in these individuals.

Keywords: Autoimmune diseases; Comorbidity; Narcolepsy type 1; Primary biliary cholangitis (PBC).

MeSH terms

  • Adult
  • Alleles
  • Cataplexy* / genetics
  • Female
  • Genetic Predisposition to Disease
  • HLA-DQ beta-Chains / genetics
  • Haplotypes
  • Humans
  • Liver Cirrhosis, Biliary* / complications
  • Liver Cirrhosis, Biliary* / epidemiology
  • Liver Cirrhosis, Biliary* / genetics
  • Narcolepsy* / complications
  • Narcolepsy* / genetics

Substances

  • HLA-DQ beta-Chains