"Post tuberculosis": the urgent need for inclusion of lung health outcomes in tuberculosis treatment trials

Anthony Byrne; Brian Allwood; Ingrid Schoeman; James Johnston; Gautam Kalyatanda; Goodman Makanda; Kevin Mortimer; Carole Mitnick; Rebecca Nightingale; Obianuju Ozoh; Andrea Rachow; Marieke Van Der Zalm

doi:10.1183/13993003.00950-2023

"Post tuberculosis": the urgent need for inclusion of lung health outcomes in tuberculosis treatment trials

Eur Respir J. 2023 Sep 9;62(3):2300950. doi: 10.1183/13993003.00950-2023. Print 2023 Sep.

Authors

Anthony Byrne^{1

2}, Brian Allwood³, Ingrid Schoeman⁴, James Johnston^{5

6}, Gautam Kalyatanda⁷, Goodman Makanda⁸, Kevin Mortimer⁹, Carole Mitnick¹⁰, Rebecca Nightingale⁹, Obianuju Ozoh¹¹, Andrea Rachow¹², Marieke Van Der Zalm^{2

13}

Affiliations

¹ St Vincent's Health Australia, Heart Lung Clinic, Sydney, Australia Anthony.Byrne@svha.org.au.
² University of New South Wales, Sydney, Australia.
³ University of Stellenbosch, Department of Medicine, Stellenbosch, South Africa.
⁴ TB Proof, Director of Advocacy and Strategy, Pretoria, South Africa.
⁵ British Columbia Centre for Disease Control, Vancouver, BC, Canada.
⁶ University of British Columbia, Faculty of Medicine, Vancouver, BC, Canada.
⁷ University of Florida, Department of Infectious Disease and Global Health, Gainesville, FL, USA.
⁸ South African Medical Research Council, Tygerberg, South Africa.
⁹ Liverpool School of Tropical Medicine, Respiratory Medicine, Liverpool, UK.
¹⁰ Harvard University, Medical School and Department of Global Health and Social Medicine, Boston, MA, USA.
¹¹ University of Lagos, Department of Medicine, Lagos, Nigeria.
¹² LMU Munich, Division of Infectious Diseases and Tropical Medicine, Munich, Germany.
¹³ Desmond Tutu TB Centre, Paediatrics and Child Health, Cape Town, South Africa.

Abstract

New TB treatment regimens are a welcome advancement. However, for the millions of TB survivors with impaired lung function and quality of life, more holistic outcome measures and the inclusion of lung function is essential in future TB treatment trials. https://bit.ly/3PWT0o2

Publication types

Letter
Comment

MeSH terms

Clinical Trials as Topic
Humans
Outcome Assessment, Health Care*
Tuberculosis* / therapy

Grants and funding

K43 TW011028/TW/FIC NIH HHS/United States