The treatment of cancer has evolved as our understanding of the underlying biological processes has improved. Yet, the efficient delivery of cancer therapeutics remains a major challenge in the filed necessitating a multidisciplinary approach that integrates knowledge obtained from diverse fields, such as chemistry, biology, engineering, and medicine. Cancer treatment aims to remove all or most of the tumor as possible and to prevent the recurrence or spread of the primary tumor. Cancer treatment involves a careful examination of the available options, which may include a combination of the major treatment methods, such as surgery with chemotherapy and/or radiation therapy. The type of therapy chosen depends on several factors, such as the location, grade, and stage of the tumor, as well as the patient's performance status. As new knowledge about cancer biology becomes available, treatments will be developed and modified in the pursuit of cancer cures to improve efficacy, precision, survivability, and quality of life. The main objective of this review is to expand our understanding of the early development of commonly applied cancer treatment strategies: surgery, chemotherapy, and radiotherapy. Keywords: Chemotherapy; Radiotherapy; Surgery; Therapy; Tumor.