Antimicrobial treatment of skin and soft tissue infections

Infect Dis Now. 2023 Nov;53(8S):104787. doi: 10.1016/j.idnow.2023.104787. Epub 2023 Sep 19.

Abstract

Bacterial skin infections are common in children, and frequently do not require systemic antibiotic therapy, particularly for superficial forms. In these cases, washing (with soap and water) and careful rinsing of the lesion are the key points of treatment. A semiotic analysis must precede any therapeutic decision to assess the appropriateness of antibiotic therapy, need for drainage (which may be spontaneous or surgical) and possible existence of symptoms related to toxin production, which are frequent signs of severity. The bacterial species most frequently implicated in children are Staphylococcus aureus and Streptococcus pyogenes. Given the low incidence of methicillin-resistant S. aureus in France (<10%), the first-line antibiotic treatment is amoxicillin-clavulanate, to which an anti-toxin treatment such as clindamycin may be added for patients with overt toxin signs.

Keywords: Antibiotherapy; Antibiotic therapy; Children; Skin infections.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Humans
  • Methicillin-Resistant Staphylococcus aureus*
  • Skin
  • Soft Tissue Infections* / drug therapy
  • Soft Tissue Infections* / epidemiology
  • Soft Tissue Infections* / microbiology
  • Staphylococcal Infections* / drug therapy

Substances

  • Anti-Bacterial Agents