Pd-Catalyzed Regioselective Hydroformylation of Olefins with HCO2H and Its Derivatives

Org Lett. 2023 Oct 6;25(39):7176-7180. doi: 10.1021/acs.orglett.3c02730. Epub 2023 Sep 27.

Abstract

An effective Pd-catalyzed regioselective hydroformylation process with N-formylsaccharin or 2,4,6-trichlorophenyl formate along with formic acid is described. Linear aldehydes can be obtained in up to 83% yield and >20:1 l/b ratio. The reaction is operationally simple without the need for external CO and H2.