Fibrinolytic shutdown (versus hypofibrinolysis) = plasmin burst followed by diminished fibrinolysis. After thrombin and plasmin burst, fibrinolysis is inhibited, mediated by increased TAFI. #TAFI #TIC #surgscience @JuliaColemanMD @CUDeptSurg @DenverHealthMed @OhioStateSurg @mitchelljayc