On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease

Nat Cell Biol. 2023 Oct;25(10):1394-1397. doi: 10.1038/s41556-023-01245-2.

Abstract

Recent findings ranging from genetics to structural biology, together with studies in human neurons, animal models and patient brains, implicate the retromer-dependent endosomal recycling pathway as both causal and common in Alzheimer’s disease.

MeSH terms

  • Alzheimer Disease*
  • Endosomes / metabolism
  • Humans
  • Protein Transport