Taking the STING out of CIN

Anouk van den Brink; Floris Foijer

doi:10.1016/j.trecan.2023.09.010

Taking the STING out of CIN

Trends Cancer. 2023 Dec;9(12):992-994. doi: 10.1016/j.trecan.2023.09.010. Epub 2023 Oct 6.

Authors

Anouk van den Brink¹, Floris Foijer²

Affiliations

¹ European Research Institute for the Biology of Ageing, University of Groningen and University Medical Center Groningen, 9713, AV, Groningen, The Netherlands.
² European Research Institute for the Biology of Ageing, University of Groningen and University Medical Center Groningen, 9713, AV, Groningen, The Netherlands. Electronic address: f.foijer@umcg.nl.

PMID: 37806895
DOI: 10.1016/j.trecan.2023.09.010

Abstract

Chromosomal instability (CIN), a hallmark of cancer, promotes cell-intrinsic inflammatory signaling. Although inflammation is generally considered tumor-suppressive, this relationship is more complex in cancers with CIN. We discuss new findings by Li et al. that can explain how cancer cells with CIN tolerate, adopt, and rewire the CIN-induced inflammatory response to fuel tumorigenesis.

Keywords: STING; cancer; chromosomal instability; inflammation; metastasis.

MeSH terms

Cell Transformation, Neoplastic
Chromosomal Instability
Humans
Neoplasms* / genetics