Background: McCune-Albright syndrome is a rare disorder characterized by polyostotic fibrous dysplasia (FD), café-au-lait skin pigmentation, and endocrine dysfunction. Extensive FD in the craniofacial region can present significant challenges in terms of disease control and carries a high risk of permanent visual impairment.
Methods: We present a case of medically and surgically resistant FD that required nine optic nerve decompressions.
Results: The condition was ultimately controlled with the use of the denosumab agent.
Conclusion: The case highlights the importance and potential efficacy of denosumab in resistant FD management, particularly in cases involving sensitive organs.
Keywords: McCune-Albright syndrome; craniofacial; denosumab; fibrous dysplasia; optic decompression.
© 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.