Report of the 2022 Banff Heart Concurrent: Focus on non-human leukocyte antigen antibodies in rejection and the pathology of "mixed" rejection

Marny Fedrigo; Gerald J Berry; Guillaume Coutance; Elaine F Reed; Chieh-Yu Lin; Alessia Giarraputo; Evan Kransdorf; Olivier Thaunat; Martin Goddard; Annalisa Angelini; Desley A H Neil; Patrick Bruneval; Jean-Paul Duong Van Huyen; Alexandre Loupy; Dylan V Miller

doi:10.1016/j.ajt.2023.10.004

Report of the 2022 Banff Heart Concurrent: Focus on non-human leukocyte antigen antibodies in rejection and the pathology of "mixed" rejection

Am J Transplant. 2024 Apr;24(4):533-541. doi: 10.1016/j.ajt.2023.10.004. Epub 2023 Oct 12.

Authors

Affiliations

¹ Department of Cardiac, Thoracic and Vascular Sciences, and Public Health, University of Padova, Padua Italy.
² Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
³ Department of cardiac surgery, La Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris (APHP), Sorbonne University Medical School, Paris France.
⁴ UCLA Immunogenetics Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
⁵ Department of Pathology and Immunology, School of Medicine, Washington University St. Louis, Missouri, USA.
⁶ Smidt Heart Institute, Cedars-Sinai Medical Center, Beverly Hills, California, USA.
⁷ Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon France.
⁸ The Cardiothoracic Transplant Unit Papworth Hospital, Cambridge, United Kingdom.
⁹ University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
¹⁰ Université de Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, Paris, France.
¹¹ Necker-Enfants Malades Hospital, Paris, France.
¹² Utah Transplant Affiliated Hospitals (UTAH) Heart Transplant Network, Intermountain Central Laboratory, Salt Lake City, Utah, USA. Electronic address: dylan.miller@imail.org.

PMID: 37838218
DOI: 10.1016/j.ajt.2023.10.004

Abstract

The Banff Heart Concurrent Session, held as part of the 16th Banff Foundation for Allograft Pathology Conference at Banff, Alberta, Canada, on September 21, 2022, focused on 2 major topics: non-human leukocyte antigen (HLA) antibodies and mixed rejection. Each topic was addressed in a multidisciplinary fashion with clinical, immunological, and pathology perspectives and future developments and prospectives. Following the Banff organization model and principles, the collective aim of the speakers on each topic was to • Determine current knowledge gaps in heart transplant pathology • Identify limitations of current pathology classification systems • Discuss next steps in addressing gaps and refining classification system.

Keywords: heart transplantation; mixed rejection; non-HLA antibodies; pathology.

MeSH terms

Canada
Graft Rejection / pathology
Heart Transplantation*
Leukocytes
Research Report
Transplantation, Homologous