Macular Thickness Is Associated with Persistent Avascular Retina in Patients with a History of Untreated Retinopathy of Prematurity

Thiago Barros de Oliveira; Benjamin K Young; Susan R Ostmo; Aaron S Coyner; Rebekah H Gensure; Brittni A Scruggs; Jamie Anderson; Darius Moshfeghi; John Peter Campbell

doi:10.1016/j.oret.2023.10.004

Macular Thickness Is Associated with Persistent Avascular Retina in Patients with a History of Untreated Retinopathy of Prematurity

Ophthalmol Retina. 2024 Feb;8(2):202-204. doi: 10.1016/j.oret.2023.10.004. Epub 2023 Oct 12.

Authors

Thiago Barros de Oliveira¹, Benjamin K Young², Susan R Ostmo², Aaron S Coyner², Rebekah H Gensure³, Brittni A Scruggs⁴, Jamie Anderson², Darius Moshfeghi⁵, John Peter Campbell⁶

Affiliations

¹ Department of Ophthalmology, Centro Universitário Christus (Unichristus), Fortaleza, Ceará, Brazil; Department of Ophthalmology, Instituto Cearense de Oftalmologia, Fortaleza, Ceará, Brazil.
² Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
³ The Eye Institute of Utah, Salt Lake City, Utah.
⁴ Department of Ophthalmology, The Mayo Clinic, Rochester, Minnesota.
⁵ Department of Ophthalmology, Stanford Byers Eye Institute, Stanford University, Palo Alto, California.
⁶ Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon. Electronic address: campbelp@ohsu.edu.

PMID: 37838277
PMCID: PMC10873111 (available on 2025-02-01)
DOI: 10.1016/j.oret.2023.10.004

Abstract

Objective:: To evaluate the relationship between central macular thickness (CMT) and the presence of persistent avascular retina (PAR) in previously premature children.

Methods:: 17 4-8 year olds with a history of retinopathy of prematurity (ROP) screening were recruited, and underwent OCT and ultra-widefield fluorescein angiography (UWFFA).

Results:: CMT was higher in PAR patients (p < 0.001). A central retina thickness above 260 μm had sensitivity/specificity of 95%/100% for detecting PAR.

Conclusions:: There may be an association between macular thickness as measured by OCT and the presence of PAR on UWFFA.

Keywords: OCT; OCTA; Persistent avascular retina; Retinopathy of prematurity..

MeSH terms

Humans
Infant, Newborn
Infant, Premature
Retina
Retinopathy of Prematurity* / complications
Retinopathy of Prematurity* / diagnosis

Abstract

MeSH terms

Grants and funding